The paper consists of an argument that goes as follows. Symbols and their elaboration into myths constitute Homo sapiens's most primitive reading of the world and the relation of humans to that world. They are, in other words, primordial units of cultural information, emerging very early in human history, representing a significant achievement in the evolution of human self‐consciousness and reflection. The classic myths of Fall and Original Sin, as well as the doctrines to which they gave rise, are further (...) interpretations of this primordial information. The doctrinal traditions of the first four centuries of Christianity are surveyed. Three sets of data as interpreted by the biological sciences are offered as resources for understanding the biogenetic grounds of the experience that the symbols, myths, and doctrines of Fall and Original Sin seek to interpret. The conclusions to be drawn are that (1) the symbolic material is indeed commensurate with the scientific understandings, and (2) the scientific interpretations deepen our understanding of the symbols, while (3) the conversation between the symbols and the science once again raises certain perennial questions about human existence. (shrink)