This paper proposes a critical examination of the wholism that Cartwright contemplates. The first part spells out the consequences of this position – notably our principled ignorance of nature as a whole. The second part considers that physical theory which is widely claimed to exhibit some sort of wholism, namely quantum physics. I sketch a wholistic model of quantum physics and compare this model to the wholism that Cartwright considers. The result is that – contrary to what Cartwright suggests – (...) we do not have to see ourselves as being ignorant of nature as such and our scientific view of nature can be quite systematic instead of being a patchwork. Finally, Cartwright’s wholism is confronted with confirmation wholism and semantic wholism. The result is again that these sorts of wholism speak against a patchwork view of our knowledge. (shrink)