Transcendental arguments are not popular in contemporary philosophy of science. They are typically seen as antinaturalistic and incapable of providing explanatory force in accounting for natural phenomena. However, when viewed as providing intelligibility to complicated concepts used in scientific reasoning, a concrete and productive role is recoverable for transcendental reasoning in philosophy of science. In this article I argue that the resources, and possibly the need, for such a role are available within a thoroughly naturalistic framework garnered from the work (...) of Hasok Chang and William Wimsatt. (shrink)