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  1. (1 other version)Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.Karla Alex & Eva C. Winkler - 2023 - Journal of Medical Ethics (doi: 10.1136/jme-2022-108888):1-9.
    Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...)
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  • (1 other version)Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.Karla Alex & Eva C. Winkler - 2024 - Journal of Medical Ethics 50 (6):398-406.
    Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...)
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