Proponents of evidence-based medicine and some philosophers of science seem to agree that knowledge of mechanisms can help solve the problem of applying results of controlled studies to target populations (‘the problem of extrapolation’). We describe the problem of extrapolation, characterize mechanisms, and outline how mechanistic knowledge might be used to solve the problem. Our main thesis is that there are four often overlooked problems with using mechanistic knowledge to solve the problem of extrapolation. First, our understanding of mechanisms is (...) often (and arguably, likely to remain) incomplete. Secondly, knowledge of mechanisms is not always applicable outside the tightly controlled laboratory conditions in which it is gained. Thirdly, mechanisms can behave paradoxically. Fourthly, as Daniel Steel points out, using mechanistic knowledge faces the problem of the ‘extrapolator’s circle’. At the same time, when the problems with mechanistic knowledge have been addressed, such knowledge can and should be used to mitigate (nothing can entirely solve) the problem of extrapolation. (shrink)

I develop a new schema for analysis of dispositions in terms of structural equations. This schema provides the means to respond to a host of problems that have been posed for other proposals, including the problem of masks, alters, mimickers, tricks, conjunctive multi-track dispositions and dispositional degrees. In the development of this new schema, I will employ structural modelling techniques to highlight features of the problem cases, thereby revealing the utility of these techniques to ongoing discussion.

The question of whether there could be a physical object that is necessarily constantly active has a long history, and it has recently arisen again in the literature on dispositions. I examine and critique two proposals for affirming the possibility of such an object. I then advocate a third option, one which is workable if paired with natural-kind essentialism. Finally I briefly outline three possible implications of this view for wider debates concerning the ontology of dispositions and natural kinds.

Causal dispositionalism developed in metaphysics of science offers a useful tool to conceptualize shallow causes in behaviour genetics, in a way such that (a) it accounts for complex aetiology and heterogeneity of effects, and (b) genetic causal contribution can be considered to be explanatory. Genes are thus causal powers that make a difference.

There is a takeover movement fast gaining influence in development economics, a movement that demands that predictions about development outcomes be based on randomized controlled trials. The problem it takes up—of using evidence of efficacy from good studies to predict whether a policy will be effective if we implement it—is a general one, and affects us all. My discussion is the result of a long struggle to develop the right concepts to deal with the problem of warranting effectiveness predictions. Whether (...) I have it right or not, these are questions of vast social importance that philosophers of science can, and should, help answer. (shrink)

In recent years, a new dispute has risen to prominence: the dispute between realists and anti-realists about causal powers. Albeit sometimes overlooked, the meta-ontological features of this “question of realism for powers” are quite peculiar. For friends and foes of causal powers have characterized their contrasting views in a variety of different ways; as existence claims, as semantic or truth-making claims, as fundamentality claims, as claims about the nature of certain properties. Not only does this multiplicity of interpretations make it (...) unclear what the genuine bone of contention is, if there is one; some of them appear to be mutually exclusive. Some light can be shed on this apparent yet widespread confusion by distinguishing three degrees of ontological involvement in dispositional truths; viz., three ways, of increasing robustness, to read ontological commitments from dispositional truths. Relatedly, by exploring the literature, and focusing on some selected examples of power realism and anti-realism, we can observe that power realists vastly disagree over the intrinsic nature ad make-up of dispositional properties. Such examples furthermore invite the thought that the question of realism for powers is best understood not as the debate around the existence of properties with a distinctive identity, but rather as a debate about metaphysical hierarchy. Finally, some anti-realists positions are indistinguishable from realist ones, using merely intensional resources: power realism is best appreciated by going hyperintensional. (shrink)