COVID-19 catalyzed a renewed focus on the interconnected nature of human health. Together with the climate crisis, it highlighted not only intra-human connections but the entanglement of human health with the health of non-human animals, plants, and ecological systems more broadly. In this article, we challenge the persistent notion that humans are ontologically distinct from the rest of nature and the ethics that flow from this understanding. Imposing this privileged view of humans has devastating consequences for beings other than humans (...) and for humans and impedes effective responses to crises. We situate the COVID-19 pandemic within the “polycrisis,” and argue that one component of addressing multidimensional crises must involve fully embracing a relational ontology and ethics. We discuss two approaches to relationality, one articulated by ecofeminists and the second inhering in an Indigenous Māori worldview. Two dominant approaches, One Health and Planetary Health, purport to take account of relational ontologies in their approaches to health, but, we argue, persist in casting the more-than-human world in an instrumental role to secure human health. We suggest that Multispecies Justice, which draws on ecofeminist and Indigenous approaches, affords a fully relational approach to health and well-being. We explore the implications of relationality, and suggest fresh ways of understanding humans’ connections with the more-than-human world. (shrink)