In 1820, J. Pelletier and J.-B. Caventou, two French pharmacist-chemists working at the Ecole de Pharmacie of Paris, extracted quinine, a new substance, from cinchona bark. We use this example to illustrate the processes which lead from a crude natural product through the isolation of an active principle to the production of a pure manufactured drug. This allows us to discuss the development of chemical analysis in relation to pharmacy, natural history, medicine and the early pharmaceutical industry. The dynamics of (...) the disciplines involved here show how organic chemistry, which was developing rapidly during these crucial years, expanded and became autonomous. Theoretical aspects and practical innovations are relevant to the scientific methods developed by the first generation of those who integrated the new chemistry into their daily work. Beyond these historical issues, this paper aims to show how a holistic approach can contribute to the debate on discovery and invention in a science that is often considered empirical. (shrink)

A chemical substance is instantiated in the material world by a number of quantities of such substance, placed in different locations. A change of location implies a change in the net of relationships entertained by the QCS with the region wherein it is found. This fact entails changes of the ontological status of the CS, as this is not fully determined by the inherent features of the CS and includes a relevant relational contribution. In order to demonstrate this thesis, we (...) have chosen to analyse the status of quantities of a same CS that are synchronically located in different spacetime regions: a synthetic lab, a lab where the QCS is turned into a material, an industrial plant, the market where the QCS gets a price and a dump waste where the QCS is discarded, respectively: Chemical substance Open image in new window material Open image in new window product Open image in new window goods Open image in new window wasteThe use of first-order predicate logic, mereology and locative logic allows carrying out a regimentation process that highlights the ontological commitments implied by the formal expressions through which each element of the aforementioned series can be described. The presence of relational properties discloses the systemic nature of the CS instantiated within a spacetime region. The implications of such an aspect are discussed. (shrink)