Using meta-metaphysical instruments, the paper analyzes the dispute between ‘reductionist’ Humean categoricalism and ‘bold’ Anti-Humean dispositionalism. It is argued that both views are non-Quinean, hence, heavyweight ontological realisms: careful analysis of specific scientific theories alone is not sufficient. Further, sophisticated philosophical reasoning is needed to defend Anti-Humeanism as well as Humeanism. The paper finally suggests that most if not all ontological disputes are unavoidably “speculative” due to essentialism which cannot be read off contemporary physical theories.