ABSTRACT This article makes a case for the contemporary relevance of Charles Sanders Peirce’s conception of rhetoric and its further fulfillment through biosemiotics and pragmatist-inflected physiological feminisms. It situates itself in an era when rhetoric is undergoing conceptual change, with the social constructivism that guided much thinking since the 1970s supplanted in part by a family of postconstructivisms. In conversation with new materialist, affective, and biological strands of rhetorical theory, the article maps questions and risks involved in developing newer conceptions (...) of rhetoric not limited to discourse, symbolic action, and exclusively human capacities. It argues that Peircean thinking provides resources for nonreductive understandings of how rhetoric emerges from life itself and is pluralistically mediated through the forming conditions and multimodal consequences that materially give it meaning. Contemporary biosemiotics and physiologically oriented feminisms like Teresa de Lauretis’s then move the promise of Peircean rhetoric closer to reality. (shrink)