This paper belongs to the research on the limit of the first incompleteness theorem. Effectively inseparable (EI) theories can be viewed as an effective version of essentially undecidable (EU) theories, and EI is stronger than EU. We examine this question: Are there minimal effectively inseparable theories with respect to interpretability? We propose tEI, the theory version of EI. We first prove that there are no minimal tEI theories with respect to interpretability (i.e., for any tEI theory T, we can effectively (...) find a theory which is tEI and strictly weaker than T with respect to interpretability). By a theorem due to Pour-EI, we have that tEI is equivalent with EI. Thus, there are no minimal EI theories with respect to interpretability. Also, we prove that there are no minimal finitely axiomatizable EI theories with respect to interpretability. (shrink)