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  1. A Qualitative Analysis of Ethical Perspectives on Recruitment and Consent for Human Intracranial Electrophysiology Studies.Joncarmen V. Mergenthaler, Winston Chiong, Daniel Dohan, Josh Feler, Cailin R. Lechner, Philip A. Starr & Jalayne J. Arias - 2021 - American Journal of Bioethics Neuroscience 12 (1):57-67.
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  • Caregiver burden and the medical ethos.Karsten Witt, Johanne Stümpel & Christiane Woopen - 2017 - Medicine, Health Care and Philosophy 20 (3):383-391.
    Are physicians sometimes morally required to ease caregiver burden? In our paper we defend an affirmative answer to this question. First, we examine the well-established principle that medical care should be centered on the patient. We argue that although this principle seems to give physicians some leeway to lessen caregivers' suffering, it is very restrictive when spelled out precisely. Based on a critical analysis of existing cases for transcending patient-centeredness we then go on to argue that the medical ethos should (...)
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  • The Ethics of Clinical Care and the Ethics of Clinical Research: Yin and Yang.Charles J. Kowalski, Raymond J. Hutchinson & Adam J. Mrdjenovich - 2017 - Journal of Medicine and Philosophy 42 (1):7-32.
    The Belmont Report’s distinction between research and the practice of accepted therapy has led various authors to suggest that these purportedly distinct activities should be governed by different ethical principles. We consider some of the ethical consequences of attempts to separate the two and conclude that separation fails along ontological, ethical, and epistemological dimensions. Clinical practice and clinical research, as with yin and yang, can be thought of as complementary forces interacting to form a dynamic system in which the whole (...)
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  • Clinical equipoise: Why still the gold standard for randomized clinical trials?Charlemagne Asonganyi Folefac & Hugh Desmond - 2024 - Clinical Ethics 19 (1):1-11.
    The principle of clinical equipoise has been variously characterized by ethicists and clinicians as fundamentally flawed, a myth, and even a moral balm. Yet, the principle continues to be treated as the de facto gold standard for conducting randomized control trials in an ethical manner. Why do we hold on to clinical equipoise, despite its shortcomings being widely known and well-advertised? This paper reviews the most important arguments criticizing clinical equipoise as well as what the most prominent proposed alternatives are. (...)
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  • Conflating Scientific With Clinical Considerations.Rieke van der Graaf & Johannes J. M. van Delden - 2009 - American Journal of Bioethics 9 (9):58-59.
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  • An apology for socratic bioethics.Franklin G. Miller & Robert D. Truog - 2008 - American Journal of Bioethics 8 (7):3 – 7.
    Bioethics is a hybrid discipline. As a theoretical enterprise it stands for untrammeled inquiry and argument. Yet it aims to influence medical practice and policy. In this article we explore tensions between these two dimensions of bioethics and examine the merits and perils of a “Socratic” approach to bioethics that challenges “the conventional wisdom.”.
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  • Why researchers cannot establish equipoise.Robert M. Veatch - 2006 - American Journal of Bioethics 6 (4):55 – 57.
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  • Eschewing Definitions of the Therapeutic Misconception: A Family Resemblance Analysis.D. S. Goldberg - 2011 - Journal of Medicine and Philosophy 36 (3):296-320.
    Twenty-five years after the term "therapeutic misconception’ (TM) first entered the literature, most commentators agree that it remains widespread. However, the majority of scholarly attention has focused on the reasons why a patient cum human subject might confuse the goals of research with the goals of therapy. Although this paper addresses the social and cultural factors that seem to animate the TM among subjects, it also fills a niche in the literature by examining why investigators too might operate under a (...)
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  • Equipoise in the Real World.Carmen Paradis - 2006 - American Journal of Bioethics 6 (4):61-63.
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  • The clinical investigator-subject relationship: a contextual approach.David B. Resnik - 2009 - Philosophy, Ethics, and Humanities in Medicine 4:16-.
    BackgroundThe nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol.Results and conclusionIn this article, I present a contextual approach to the investigator-subject relationship. The extent of the investigator's duty (...)
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  • Evidence-based equipoise and research responsiveness.Scott D. Halpern - 2006 - American Journal of Bioethics 6 (4):1 – 4.
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  • Extensions and Refinements of the Equipoise Concept in International Clinical Research: Would Benjamin Freedman Approve?Howard Mann - 2006 - American Journal of Bioethics 6 (4):67-69.
    In his article “The Real Problem of Equipoise,” Chiong (2006) advances arguments that culminate in an assertion that the equipoise requirement “must be given uP′ if international clinical research...
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  • (1 other version)Data and Safety Monitoring Boards: Some Enduring Questions.Charles J. Kowalski & Jan L. Hewett - 2009 - Journal of Law, Medicine and Ethics 37 (3):496-506.
    Data Safety and Monitoring Boards have been referred to as a “growth industry,” and this trend continues to be fueled by recent FDA guidance and the NIH's requirement that DSMBs be employed in virtually all phase III clinical trials. The widening role of DSMBs has been sporadically questioned on ethical grounds, but growth has continued, despite the fact that many of the questions endure, unanswered, save for repeated references to safeguarding the scientific integrity of trials. This may be about to (...)
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  • Role-Differentiated Morality: The Need to Consider Institutions, Not Just Individuals.Ronald A. Lindsay - 2006 - American Journal of Bioethics 6 (4):70-72.
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  • The moral foundations of equipoise and its role in international research.Alex John London - 2006 - American Journal of Bioethics 6 (4):48 – 51.
    In “The Real Problem With Equipoise,” Chiong (2006) raises two distinct, but interrelated issues concerning the concept of equipoise. The first deals with the role of equipoise in evaluating intern...
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  • Are there three or four distinct types of medical practice?Howard Brody - 2006 - American Journal of Bioethics 6 (4):51 – 53.
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  • Splitting the Difference Position.Abraham P. Schwab - 2006 - American Journal of Bioethics 6 (4):74-76.
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  • Defending the Distinction Between Research and Medical Care.Paul Litton - 2006 - American Journal of Bioethics 6 (4):63-66.
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  • (1 other version)Data and Safety Monitoring Boards: Some Enduring Questions.Charles J. Kowalski & Jan L. Hewett - 2009 - Journal of Law, Medicine and Ethics 37 (3):496-506.
    Data Safety and Monitoring Boards were introduced in the 1960s to monitor data in clinical trials to ensure subject safety. It was thought important that DSMB members be experts in the field of interest, but not otherwise involved in the study in order to maximize objectivity. Since then, the use of DSMBs has increased dramatically, and their scope has expanded to include scientific issues — in particular, to avoid bias that can result when trials are stopped early because of evidence (...)
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  • Physicians as researchers: Difficulties with the "similarity position".David Wasserman, Deborah S. Hellman & Robert Wachbroit - 2006 - American Journal of Bioethics 6 (4):57 – 59.
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  • Reconceiving the Therapeutic Obligation.D. Merli & J. A. Smith - 2014 - Journal of Medicine and Philosophy 39 (1):55-74.
    The “therapeutic obligation” is a physician’s duty to provide his patients with what he believes is the best available treatment. We begin by discussing some prominent formulations of the obligation before raising two related considerations against those formulations. First, they do not make sense of cases where doctors are permitted to provide suboptimal care. Second, they give incorrect results in cases where doctors are choosing treatments in challenging epistemic environments. We then propose and defend an account of the therapeutic obligation (...)
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  • Equipoise and the Ethics of Clinical Research Revisited.Franklin G. Miller - 2006 - American Journal of Bioethics 6 (4):59-61.
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  • Clinical ethics versus clinical research.Paul S. Appelbaum & Charles W. Lidz - 2006 - American Journal of Bioethics 6 (4):53 – 55.
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  • Ethical Considerations in Ending Exploratory Brain–Computer Interface Research Studies in Locked-in Syndrome.Eran Klein, Betts Peters & Matt Higger - 2018 - Cambridge Quarterly of Healthcare Ethics 27 (4):660-674.
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  • What Do I Tell My Patient?Dan R. Thompson - 2006 - American Journal of Bioethics 6 (4):66-67.
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  • The Law of Mass Action.Howard Trachtman - 2006 - American Journal of Bioethics 6 (4):72-74.
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  • Confusions in the equipoise concept and the alternative of fully informed overlapping rational decisions.David W. Chambers - 2011 - Medicine, Health Care and Philosophy 14 (2):133-142.
    Despite its several variations, the central position of equipoise is that subjects in clinical experiments should not be randomized to conditions when others believe that better alternatives exist. This position has been challenged over issues of which group in the medical or research community is authorized to make that determination, and it has been argued that informed consent provides sufficient ethical protection for participants independent of equipoise. In this paper I frame ethical participation in clinical research as a two-party decision (...)
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