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  1. The family rule: a framework for obtaining ethical consent for medical interventions from children.D. M. Foreman - 1999 - Journal of Medical Ethics 25 (6):491-500.
    Children's consent to treatment remains a contentious topic, with confusing legal precepts and advice. This paper proposes that informed consent in children should be regarded as shared between children and their families, the balance being determined by implicit, developmentally based negotiations between child and parent--a "family rule" for consent. Consistent, operationalized procedures for ethically obtaining consent can be derived from its application to both routine and contentious situations. Therefore, use of the "family Rule" concept can consistently define negligent procedure in (...)
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  • Assent in paediatric research: theoretical and practical considerations.D. S. Wendler - 2006 - Journal of Medical Ethics 32 (4):229-234.
    Guidelines around the world require children to provide assent for their participation in most research studies. Yet, little further guidance is provided on how review committees should implement this requirement, including which children are capable of providing assent and when the requirement for assent may be waived on the grounds that the research offers participating children the potential for important clinical benefit. The present paper argues that the assent requirement is supported by the importance of allowing children who are capable (...)
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  • Is it in a neonate's best interest to enter a randomised controlled trial?P. Allmark - 2001 - Journal of Medical Ethics 27 (2):110-113.
    Clinicians are required to act in the best interest of neonates.However, it is not obvious that entry into a randomised controlled trial (RCT) is in a neonate’s best interest because such trials often involve additional onerous procedures (such as intramuscular injections) in return for which the neonate receives unproven treatment or a placebo.On the other hand, neonatology needs to develop its evidence base, and RCTs are central to this task. The solution posited here is based on two points. First, “best (...)
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  • Delays and diversity in the practice of local research ethics committees.A. H. Ahmed & K. G. Nicholson - 1996 - Journal of Medical Ethics 22 (5):263-266.
    OBJECTIVES: To compare the practices of local research ethics committees and the time they take to obtain ethical approval for a multi-centre study. DESIGN: A retrospective analysis of outcome of applications for a multi-centre study to local research ethics committees. SETTING: Thirty-six local research ethics committees covering 38 district health authorities in England. MAIN MEASURES: Response of chairmen and women, the time required to obtain approval, and questions asked in application forms. RESULTS: We received replies from all 36 chairmen contacted: (...)
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  • Deception of children in research.Merle Spriggs & Lynn Gillam - 2015 - Journal of Medical Ethics 41 (2):179-182.
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  • Canaries in the mines: children, risk, non-therapeutic research, and justice.M. Spriggs - 2004 - Journal of Medical Ethics 30 (2):176-181.
    The Kennedy Krieger lead paint study received a lot of attention after a US Court of Appeals ruled that a parent cannot consent to the participation of a child in non-therapeutic research. The ruling has raised fears that, if it goes unchallenged, valuable research might not proceed and ultimately all children would be harmed. The author discusses significant aspects of the study that have been neglected, and argues that the study was unethical because it involved injustice and its design meant (...)
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