Linkage (or genetic) maps are graphs, which are intended to represent the linear ordering of genes on the chromosomes. They are constructed on the basis of statistical data concerning the transmission of genes. The invention of this technique in 1913 was driven by Morgan's group's adoption of a set of hypotheses concerning the physical mechanism of heredity. These hypotheses were themselves grounded in Morgan's defense of the chromosome theory of heredity, according to which chromosomes are the physical basis of genes. (...) In this paper, I analyze the 1919 debate between William Castle and Morgan's group, about the construction of genetic maps. The official issue of the debate concerns the arrangement of genes on chromosomes. However, the disputants tend to carry out the discussions about how one should model the data in order to draw predictions concerning the transmission of genes; the debate does not bear on the data themselves, nor does it focus on the hypotheses explaining these data. The main criteria that are appealed to by the protagonists are simplicity and predictive efficacy. However, I show that both parties' assessments of the simplicity and predictive efficacy of different ways of modeling the data themselves depend on background theoretical positions. I aim at clarifying how preference for a given model and theoretical commitments articulate. (shrink)

Humans can think about their conscious experiences using a special class of ?phenomenal? concepts. Psychophysical identity statements formulated using phenomenal concepts appear to be contingent. Kripke argued that this intuited contingency could not be explained away, in contrast to ordinary theoretical identities where it can. If the contingency is real, property dualism follows. Physicalists have attempted to answer this challenge by pointing to special features of phenomenal concepts that explain the intuition of contingency. However no physicalist account of their distinguishing (...) features has proven to be satisfactory. Leading accounts rely on there being a phenomenological difference between tokening a physical-functional concept and tokening a phenomenal concept. This paper shows that existing psychological data undermine that claim. The paper goes on to suggest that the recalcitrance of the intuition of contingency may instead by explained by the limited means people typically have for applying their phenomenal concepts. Ways of testing that suggestion empirically are proposed. (shrink)

William Bateson vigorously objected to the assumptions within the chromosome theory of heredity proposed by T. H. Morgan because he perceived inadequate experimental data that could substantiate the theory. Those objections were largely resolved by 1921, and Bateson reluctantly accepted the basic assumption that chromosomes carried the genetic factors from one generation to the next. Bateson's own research at that time on developmental genetics seemed out of touch with the general tone of the genetics field, and the chromosome theory did (...) not provide illuminating mechanisms that elucidated phenomena such as plant variegations or chimeras. Bateson imagined a general theory of heredity and development based on vortices and waves, concepts he borrowed from contemporary physics. For decades he sought to devise an intellectually and aesthetically satisfying theory to eventually explain evolution in genetic terms, but his aspirations remained unfulfilled when he died in 1926. (shrink)

In 1891 Cambridge biologist William Bateson (1861–1926) announced his idea that the symmetrical segmentation in living organisms resulted from energy peaks of some vibratory force acting on tissues during morphogenesis. He also demonstrated topographically how folding a radially symmetric organism could produce another with bilateral symmetry. Bateson attended many lectures at the Cambridge Philosophical Society and viewed mechanical models prepared by eminent physicists that illustrated how vibrations affected materials. In his subsequent research, Bateson utilized analogies and metaphors based upon his (...) observations of nature to build a thought model on the effects of vibrations on living tissue, because he realized that the chemistry and biology of his day lacked technologies to perform actual experiments on the subject. He concluded the production of organic segmentation was both a chemical and mechanical phenomenon. By the time of his death Bateson had incorporated new ideas about embryonic organizer regions to suggest a center from which a rhythmic force emanated and then produced the observed repetitive segmentation as a common feature in living organisms. (shrink)

As a defender of the fundamental importance of Mendel’s experiments for understanding heredity, the English biologist William Bateson did much to publicize the usefulness of Mendelian science for practical breeders. In the course of his campaigning, he not only secured a reputation among breeders as a scientific expert worth listening to but articulated a vision of the ideal relations between pure and applied science in the modern state. Yet historical writing about Bateson has tended to underplay these utilitarian elements of (...) his program, to the extent of portraying him, notably in still-influential work from the 1960s and 1970s, as a type specimen of the scientist who could not care less about application. This paper offers a corrective view of Bateson himself—including the first detailed account of his role as an expert witness in a courtroom dispute over the identity of a commercial pea variety—and an inquiry into the historiographic fate of his efforts in support of Mendelism’s productivity. For all that a Marxian perspective classically brings applied science to the fore, in Bateson’s case, and for a range of reasons, it did the opposite during the Cold War. (shrink)

Physics matters less than we once thought to the making of Mendel. But it matters more than we tend to recognize to the making of Mendelism. This paper charts the variety of ways in which diverse kinds of physics impinged upon the Galtonian tradition which formed Mendelism’s matrix. The work of three Galtonians in particular is considered: Francis Galton himself, W. F. R. Weldon and William Bateson. One aim is to suggest that tracking influence from physics can bring into focus (...) important but now little-remembered flexibilities in the Galtonian tradition. Another is to show by example why generalizations about what happens when ‘physics’ meets ‘biology’ require caution. Even for a single research tradition in Britain in the decades around 1900, these categories were large, containing multitudes. (shrink)

: Testing the claims that scientists make is extremely difficult. Testing the claims that philosophers of science make about science is even more difficult, difficult but not impossible. I discuss three efforts at testing the sorts of claims that philosophers of science make about science: the influence of scientists' age on the alacrity with which they accept new views, the effect of birth order on the sorts of contributions that scientists make, and the role of novel predictions in the acceptance (...) of new scientific views. Without attempting to test philosophical claims, it is difficult to know what they mean. (shrink)