Recent years have seen an explosion of interest in the field of ‘art-science’ collaborations for their perceived capacity to develop new cultural understandings of technology and science. In this article, and through an engagement with the philosophy of Gilbert Simondon, I argue that if art-science represents an important site for the formation of an alternate technical culture today, then it is because of the new technical mentalities that such practices might cultivate. Here, creating a new technical mentality is more than (...) just a representational concern with enhancing ‘public awareness’ of technology, instead referring to more material transformations in our embodied capacities for perceiving and affectively engaging with technologies. I flesh this potential out through an encounter with work of Art Orienté objet, whose art-science collaborations challenge the anthropocentric and utilitarian mentalities of contemporary bioscience through explorations of the transindividual conditions of human embodiment and its material immersion within nonhuman ecologies. (shrink)