In this paper, we use the concept of very true operator to pre-semi-Nelson algebras and investigate the properties of very true pre-semi-Nelson algebras. We study the very true N-deductive systems and use them to establish the uniform structure on very true pre-semi-Nelson algebras. We obtain some properties of this topology. Finally, the corresponding logic very true semi-intuitionistic logic with strong negation is constructed and algebraizable of this logic is proved based on very true semi-Nelson algebras.