We begin by distinguishing computationalism from a number of other theses that are sometimes conflated with it. We also distinguish between several important kinds of computation: computation in a generic sense, digital computation, and analog computation. Then, we defend a weak version of computationalism—neural processes are computations in the generic sense. After that, we reject on empirical grounds the common assimilation of neural computation to either analog or digital computation, concluding that neural computation is sui generis. Analog computation requires continuous (...) signals; digital computation requires strings of digits. But current neuroscientific evidence indicates that typical neural signals, such as spike trains, are graded like continuous signals but are constituted by discrete functional elements (spikes); thus, typical neural signals are neither continuous signals nor strings of digits. It follows that neural computation is sui generis. Finally, we highlight three important consequences of a proper understanding of neural computation for the theory of cognition. First, understanding neural computation requires a specially designed mathematical theory (or theories) rather than the mathematical theories of analog or digital computation. Second, several popular views about neural computation turn out to be incorrect. Third, computational theories of cognition that rely on non-neural notions of computation ought to be replaced or reinterpreted in terms of neural computation. (shrink)

In this article, I argue that the artificial components of hybrid bionic systems do not play a direct explanatory role, i.e., in simulative terms, in the overall context of the systems in which they are embedded in. More precisely, I claim that the internal procedures determining the output of such artificial devices, replacing biological tissues and connected to other biological tissues, cannot be used to directly explain the corresponding mechanisms of the biological component(s) they substitute (and therefore cannot be used (...) to explain the local mechanisms determining an overall biological or cognitive function replicated by such bionic models). I ground this analysis on the use of the Minimal Cognitive Grid (MCG), a novel framework proposed in Lieto (Cognitive design for artificial minds, 2021) to rank the epistemological and explanatory status of biologically and cognitively inspired artificial systems. Despite the lack of such a direct mechanistic explanation from the artificial component, however, I also argue that the hybrid bionic systems can have an indirect explanatory role similar to the one played by some AI systems built by using an overall structural design approach (but including the partial adoption of functional components). In particular, the artificial replacement of part(s) of a biological system can provide i) a local functional account of that part(s) in the context of the overall functioning of the hybrid biological–artificial system and ii) global insights about the structural mechanisms of the biological elements connected to such artificial devices. (shrink)

This paper addresses concerns raised recently by Datteri (Biol Philos 24:301–324, 2009) and Craver (Philos Sci 77(5):840–851, 2010) about the use of brain-extending prosthetics in experimental neuroscience. Since the operation of the implant induces plastic changes in neural circuits, it is reasonable to worry that operational knowledge of the hybrid system will not be an accurate basis for generalisation when modelling the unextended brain. I argue, however, that Datteri’s no-plasticity constraint unwittingly rules out numerous experimental paradigms in behavioural and systems (...) neuroscience which also elicit neural plasticity. Furthermore, I propose that Datteri and Craver’s arguments concerning the limitations of prosthetic modelling in basic neuroscience, as opposed to neuroengineering, rests on too narrow a view of the ways models in neuroscience should be evaluated, and that a more pluralist approach is needed. I distinguish organisational validity of models from mechanistic validity. I argue that while prosthetic models may be deficient in the latter of these explanatory virtues because of neuroplasticity, they excel in the former since organisational validity tracks the extent to which a model captures coding principles that are invariant with plasticity. Changing the brain, I conclude, is one viable route towards explaining the brain. (shrink)

Nicholas Maxwell takes on the ambitious project of explaining, both epistemologically and metaphysically, the physical universe and human existence within it. His vision is appealing; he unites the physical and the personal by means of the concepts of aim and value, which he sees as the keys to explaining traditional physical puzzles. Given the current popularity of theories of goal-oriented dynamical systems in biology and cognitive science, this approach is timely. But a large vision requires firm and nuanced arguments to (...) support it. Here Maxwell's work is weakest; his arguments for contingent mind-body identity and for free will, on which his larger theory depends, are inadequate. The book is valuable both for its comprehensive view of the human condition and its mysteries, and for its demonstration of the difficulties in making such a view coherent. (shrink)

The use of machine learning instead of traditional models in neuroscience raises significant questions about the epistemic benefits of the newer methods. I draw on the literature on model intelligibility in the philosophy of science to offer some benchmarks for the interpretability of artificial neural networks used as a predictive tool in neuroscience. Following two case studies on the use of ANN’s to model motor cortex and the visual system, I argue that the benefit of providing the scientist with understanding (...) of the brain trades off against the predictive accuracy of the models. This trade-off between prediction and understanding is better explained by a non-factivist account of scientific understanding. (shrink)

What can interactive robots offer to the study of social behaviour? Philosophical reflections about the use of robotic models in animal research have focused so far on methods involving robots which do not interact with the target system. Yet, leading researchers have claimed that interactive robots may constitute powerful experimental tools to study collective behaviour. Can they live up to these epistemic expectations? This question is addressed here by focusing on a particular experimental methodology involving interactive robots which has been (...) often adopted in animal research. This methodology is shown to differ from other robot-supported methods for the study of animal behaviour analysed in the philosophical literature, chiefly including the synthetic method. It is also discussed whether biomimicry and acceptability are necessary for an interactive robot to be sensibly used in animal research according to this method. (shrink)

Bionic systems, connecting biological tissues with computer or robotic devices through brain–machine interfaces, can be used in various ways to discover biological mechanisms. In this article I outline and discuss a “stimulation-connection” bionics-supported methodology for the study of the brain, and compare it with other epistemic uses of bionic systems described in the literature. This methododology differs from the “synthetic”, simulative method often followed in theoretically driven Artificial Intelligence and cognitive science, even though it involves machine models of biological systems. (...) I also bring the previous analysis to bear on some claims on the epistemic value of bionic technologies made in the recent philosophical literature. I believe that the methodological reflections proposed here may contribute to the piecewise understanding of the many ways bionic technologies can be deployed not only to restore lost sensory-motor functions, but also to discover brain mechanisms. (shrink)

The aim of the paper is to present and analyze problems associated with the mechanisms of auditory perception (especially those responsible for speech perception), their specific disorders and functions. I discuss research on speech perception in the broader theoretical context of the mechanistic model of scientific explanation and the perspective of cognitive implantology that explores the possibilities for building hybrid auditory systems.

Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...) computational models. Drawing on epistemological work in the philosophy of medicine, we explain why these two methods, while powerful, are neither truly personalised nor, epistemologically speaking, novel strategies. Both are forms of correlational black box. We then argue that the iPSC models would count as a new kind of black box. They would not rely entirely on mechanistic knowledge, and they would utilise correlational evidence in a different way from other strategies—a way that would enable personalised predictions. In arguing that the iPSC models would present a novel method of gaining evidence for clinical practice, we provide an epistemic analysis that can help to inform the practical, regulatory, and ethical challenges of developing an iPSC system. (shrink)

The mind's arrows , by Clark Glymour, combines several of the author's previous essays on causal inference. Glymour deploys causal Bayes nets (CBNs) to provide a descriptive psychological model of human causal inference and a prescriptive model for making inferences in cognitive neuropsychology and the social sciences. Though The mind's arrows is highly original and provocative, its labyrinthine organization and technical style render it inaccessible to the uninitiated. Here we attempt to distill, package and dress some of Glymour's more interesting (...) theses. We note that the psychological model is developed with minimal attention to evidence concerning human causal inference and that his prescriptive models fail to do justice either to the many sources of evidence in cognitive neuropsychology or to the serious challenges of making causal inferences in the social sciences. Considerable work remains to be done to complete Glymour's ambitious projects and to clearly communicate them to others. (shrink)