Do we owe anything to our genetic relatives qua genetic relatives? The philosophical literature has primarily addressed this question in the context of procreation. But genetic matching databases raise the question of whether we owe anything to previously unknown genetic relatives. This article argues that influential philosophical arguments regarding moral claims to know one’s genetic origins (sometimes referred to as a ‘right to know’) in the context of gamete donation have implications for a broader set of claims. First, these arguments (...) imply more than a claim to know the identity of a genetic relative; the interests which they invoke can only be satisfied through a relationship. Second, the scope of the claims is broader than tends to be acknowledged: even if procreators have special obligations towards their offspring, these arguments imply that weighty moral claims can be made against other genetic relatives in many different contexts. (shrink)

Mitochondrial replacement therapy has been developed in order to prevent the transmission of mitochondrial mutations, yet it raises ethical concerns, particularly regarding the involvement of third-party DNA and the risks associated with donor procedures. This paper explores an alternative approach using synthetic DNA (synDNA) to construct mitochondrial organelles, thereby bypassing the need for donor oocytes and bypassing risks to donors. We argue that those who support mitochondrial replacement techniques as an ethically acceptable means of preventing the transmission of mitochondrial disease (...) should consider the use of synthetic mitochondria as a preferable ethical alternative, should it prove technically viable. That this will be viable is more than we can demonstrate here. However, progress in synDNA technology suggests that it is not unreasonable to think that synthetic mitochondria creation is feasible, and perhaps even probable. (shrink)