Purpose. The article is aimed to outline Locke’s position on the basic principles of proper human behavior. Its implementation involves: a) review of the research literature concerning the place of anthropological motive in philosophizing and b) research of his interpretation of human nature and the role of the rational component. Theoretical basis. The author’s approach is based on the conceptual provisions of phenomenology and existentialism. Originality. The work considers the teaching of Locke as the author of the original concept of (...) human nature, which is closely related to the understanding of ethical issues. It is proved that its meaningful development involves the identification of the main components of human nature in the process of determining the basic principles of personality behavior. The original conception of the thinker on the irrational component of human nature and the ways of its rationalization is analyzed. Conclusions. It is substantiated that Locke’s philosophical heritage is not reduced to depersonalized empiricism as epistemology, and his teaching about human is not limited to the abstract study of their rational component. The thinker connects the request of his own epoch with the new vision of human and the basic principles of their behavior on the basis of rationality. Locke is looking for the ways to master the irrational component of human nature and is convinced that in the era of the scientific revolution, the basis of human behavior should be rationality. Locke considers human freedom to be one of the key moments of human nature. (shrink)