The article intends to show the significance of Ch. Peirce’s ideas for the development of contemporary philosophy, to find out the main directions of his criticism of the principles of Cartesian and more broadly modern philosophy (where it comes from Descartes) and to consider the positive program of his philosophy, which he offers as an alternative to Modern philosophy. Peirce starts from a pragmatic and semiotic approach to human nature, consciousness and cognition. Thanks to this approach, he managed to undermine (...) the key ideas of the modern understanding of cognition, human, language, namely: individualism, linguistic atomism, dogmatism, dualism, representationism, nominalism, foundationalism, etc. And, instead, to propose a new theory of knowledge, a new ontology and anthropology. Peirce asserts the indirectness of human cognition by signs (linguistic, cultural, sensory), the impossibility of introspection and intuition, advocates holism, fallibilism, pragmatism, realism, synechism, inferentialism and offers a new understanding of the personality — all this makes him a relevant and contemporary thinker. Peirce’s ideas offer a fresh perspective on modern scientific practice. Peirce’s rethinking of the foundations of knowledge puts him alongside many thinkers of the 20th and 21st centuries. The development of his ideas can be seen in modern anthropology, epistemology, research on artificial intelligence, semiotics, etc. The article is divided into four subsections, which are devoted to the main directions of Peirce’s criticism of Descartes’ philosophy: in the first — against Descartes’ skeptical methodology, Peirce puts the concept of fallibilism and the principle of belief, in the second — Peirce denies the possibility of intuition and proves the indirectness of our cognition by signs, in the third — it is about the advantages of the semiotic and communicative approach over individualism and linguistic atomism, in the fourth — Descartes’ nominalism and dualism, Peirce contrasts the realist approach and his theory of synechism, as well as semiotic anthropology. (shrink)