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  1. Can Aging Research Generate a Theory of Health?Jonathan Sholl - 2021 - History and Philosophy of the Life Sciences 43 (2):1-26.
    While aging research and policy aim to promote ‘health’ at all ages, there remains no convincing explanation of what this ‘health’ is. In this paper, I investigate whether we can find, implicit within the sciences of aging, a way to know what health is and how to measure it, i.e. a theory of health. To answer this, I start from scientific descriptions of aging and its modulators and then try to develop some generalizations about ‘health’ implicit within this research. After (...)
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  • Geneticization in MIM/OMIM®? Exploring Historic and Epistemic Drivers of Contemporary Understandings of Genetic Disease.Rachel A. Ankeny - 2017 - Journal of Medicine and Philosophy 42 (4):367-384.
    Prior to the genomic sequencing era, the bible for those working in clinical genetics was McKusick’s Mendelian Inheritance in Man, which appeared in multiple editions between the 1960s and the late 1990s. This catalogue was organized according to general patterns of inheritance and focused on phenotypes. Beginning in the mid-1980s, it was replaced by Online Mendelian Inheritance in Man, a continuously updated catalogue documenting molecular relationships between genetic variation and phenotypic expression. This paper explores this resource’s evolution with attention to (...)
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  • Mechanistic and Topological Explanations in Medicine: The Case of Medical Genetics and Network Medicine.Marie Darrason - 2018 - Synthese 195 (1):147-173.
    Medical explanations have often been thought on the model of biological ones and are frequently defined as mechanistic explanations of a biological dysfunction. In this paper, I argue that topological explanations, which have been described in ecology or in cognitive sciences, can also be found in medicine and I discuss the relationships between mechanistic and topological explanations in medicine, through the example of network medicine and medical genetics. Network medicine is a recent discipline that relies on the analysis of various (...)
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