This paper investigates the use of theories of mechanics to provide answers to questions in the metaphysics of spatial location and persistence. Investigating spatial location, I find that in classical physics bodies pertend the region of space at which they are exactly located, while a quantum system spans a region at which it is exactly located. Following this analysis, I present a ‘no-go’ result which shows that quantum mechanics restricts the available options for locational persistence theories in an interesting way: (...) it demonstrates that the spatiotemporal path of a persisting thing is discrete in time. This leads to unpalatable consequences for both perdurantists and endurantists. In particular, I argue that Butterfield's ‘anti-pointilliste’ perdurantism is ruled out, and show that endurantists relying on immanent causation run into trouble. I conclude by suggesting the revival of Whitehead's alternative mode of persistence called ‘reiteration.’. (shrink)