This paper defends the Quine-Putnam mathematical indispensability argument against two objections raised by Penelope Maddy. The objections concern scientific practices regarding the development of the atomic theory and the role of applied mathematics in the continuum and infinity. I present two alternative accounts by Stephen Brush and Alan Chalmers on the atomic theory. I argue that these two theories are consistent with Quine’s theory of scientific confirmation. I advance some novel versions of the indispensability argument. I argue that these new (...) versions accommodate Maddy’s history of the atomic theory. Counter-examples are provided regarding the role of the mathematical continuum and mathematical infinity in science. (shrink)