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  1. Going big by going small: Trade-offs in microbiome explanations of cancer.Emily C. Parke & Anya Plutynski - 2023 - Studies in History and Philosophy of Science Part A 97 (C):101-110.
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  • Evaluating the Validity of Animal Models of Mental Disorder: From Modeling Syndromes to Modeling Endophenotypes.Hein van den Berg - 2022 - History and Philosophy of the Life Sciences 44 (4):1-26.
    This paper provides a historical analysis of a shift in the way animal models of mental disorders were conceptualized: the shift from the mid-twentieth-century view, adopted by some, that animal models model syndromes classified in manuals such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), to the later widespread view that animal models model component parts of psychiatric syndromes. I argue that in the middle of the twentieth century the attempt to maximize the face validity of animal models (...)
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  • An African ethical perspective on South Africa's regulatory frameworks governing animals in research.Yolandi M. Coetser - 2022 - Studies in History and Philosophy of Science Part A 92 (C):119-128.
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  • Validating Animal Models.Nina A. Atanasova - 2015 - Theoria: Revista de TeorĂ­a, Historia y Fundamentos de la Ciencia 30 (2):163.
    This paper responds to a recent challenge for the validity of extrapolation of neurobiological knowledge from laboratory animals to humans. According to this challenge, experimental neurobiology, and thus neuroscience, is in a state of crisis because the knowledge produced in different laboratories hardly generalizes from one laboratory to another. Presumably, this is so because neurobiological laboratories use simplified animal models of human conditions that differ across laboratories. By contrast, I argue that maintaining a multiplicity of experimental protocols and simple models (...)
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  • Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950.Rachel A. Ankeny, Sabina Leonelli, Nicole C. Nelson & Edmund Ramsden - 2014 - Science in Context 27 (3):485-509.
    ArgumentWe examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the (...)
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