Karl Popper and Paul Feyerabend were among the most influential philosophers of science of the twentieth century. Extensive studies have been dedicated to the development of their controversial relationship, which saw Feyerabend turning from a student and supporter of Popper to one of his harshest critics. Yet, it is not as well known that the rift between Popper and Feyerabend arose mainly in the context of their studies on the foundations of quantum mechanics, which has been the main subject of (...) their discussions for about two decades. This paper reconstructs in detail their diatribe over the foundations of quantum mechanics, emphasising also the major role that their personal relationship played in their distancing. (shrink)