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When mechanisms are not enough: The origin of eukaryotes and scientific explanation

In Alexander Christian, David Hommen, Gerhard Schurz & N. Retzlaff (eds.), Philosophy of Science. European Studies in Philosophy of Science, vol 9. Dordrecht, Netherlands: pp. 95-115 (2018)

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  1. Principled Mechanistic Explanations in Biology: A Case Study of Alzheimer's Disease.Sepehr Ehsani - manuscript
    Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...)
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