To explain the phenomena in the world of our experience, to answer the question “why?” rather than only the question “what?”, is one of the foremost objectives of all rational inquiry; and especially, scientific research in its various branches strives to go beyond a mere description of its subject matter by providing an explanation of the phenomena it investigates. While there is rather general agreement about this chief objective of science, there exists considerable difference of opinion as to the function (...) and the essential characteristics of scientific explanation. In the present essay, an attempt will be made to shed some light on these issues by means of an elementary survey of the basic pattern of scientific explanation and a subsequent more rigorous analysis of the concept of law and of the logical structure of explanatory arguments. (shrink)

In this article, I analyze Quine’s conception of science, which is a radical defence of extensionalism on the grounds that first‐order logic is the most adequate logic for science. I examine some criticisms addressed to it, which show the role of modalities and probabilities in science and argue that Quine’s treatment of probability minimizes the intensional character of scientific language and methods by considering that probability is extensionalizable. But this extensionalizing leads to untenable results in some cases and is not (...) consistent with the fact that Quine himself admits confirmation which includes probability. Quine’s extensionalism does not account for this fact and then seems unrealistic, even if science ought to be extensional in so far as it is descriptive and mathematically expressible. (shrink)

As reflexões metodológicas de Poincaré sobre a modelação mecânica dos fenômenos, as teorias físicas, a hierarquização das leis e a evolução do seu estatuto e sistema são susceptíveis de uma leitura kantiana que exibe a função constitutiva das matemáticas e a função reguladora dos princípios de conveniência e dos princípios da física, correspondendo estes a uma importante etapa na evolução das teorias físicas. The methodological reflections of Poincaré on the mechanical modeling of phenomena, physical theories, the hierarchy of laws and (...) the evolution of their status and system are illuminated by a Kantian reading that displays the constitutive function of mathematics and the regulative function of principles of convenience and of the principles of physics, these corresponding to an important step in the evolution of physical theories. (shrink)

In the first half of this dissertation, I develop a heuristic methodology for analyzing scientific solutions to the problem of underdetermination. Heuristics are rough-and-ready procedures used by scientists to construct models, design experiments, interpret evidence, etc. But as powerful as they are, heuristics are also error-prone. Therefore, I argue that they key to prudently using a heuristic is the articulation of meta-heuristics---guidelines to the kinds of problems for which a heuristic is well- or ill-suited. Given that heuristics will introduce certain (...) errors into our scientific investigations, I emphasize the importance of a particular category of meta-heuristics involving the search for robust evidence. Robustness is understood to be the epistemic virtue bestowed by agreement amongst multiple modes of determination. The more modes we have at our disposal, and the more these confirm the same result, the more confident can we be that a result is not a mere artifact of some heuristic simplification. Through an analysis of case-studies in the philosophy of biology and clinical trials, I develop a principled method for modeling and evaluating heuristics and robustness claims in a qualitative problem space. The second half of the dissertation deploys the heuristic methodology to address ethical and epistemological issues in the science of clinical trials. To that end, I develop a network model for the problem space of clinical research, capable of representing the various kinds of experiments, epistemic relationships, and ethical justifications intrinsic to the domain. I then apply this model to ongoing research with the antibacterial agent, moxifloxacin, for the treatment of tuberculosis, tracking its development from initially successful and promising in vitro and animal studies to its disappointing and discordant performance across five human efficacy trials. Given this failure to find a robust result with moxifloxacin across animal and human studies, what should researchers now do? While my final analysis of this case does not definitively answer that question, I demonstrate how my methodology, unlike a statistical meta-analysis, helps to clarify the directions for further research. (shrink)

La tesis principal defendida por Michael Tooley en su artículo The Nature of Laws sostiene que son las relaciones entre universales los auténticos hacedores de verdad de los enunciados nomológicos y de las leyes. Esta tesis bien podría no atraer a gran cantidad de filósofos, puesto que implica un realismo fuerte con respecto a los universales. En nuestro propio caso, creemos que son más graves algunas inconsistencias en las cuales cae el autor a la hora de fundamentar su concepción o (...) de mostrar los supuestos atractivos de su postura con respecto a las de sus adversarios. El presente trabajo se propone identificar tales inconsistencias y demostrar que su visión de los enunciados nomológicos asume un fuerte compromiso con el platonismo. (shrink)

In the introduction to his famous book, La Science et l’hypothèse, Poincaré remarks on the necessary role and legitimacy of hypotheses. He establishes a triple classification of hypotheses, dividing them into verifiable, useful, and apparent. However, in chapter 9, entitled ‘Les hypothèses en physique’, he gives a slightly different triadic classification: natural hypotheses, indifferent hypotheses, and real generalizations. The origin of this second classification is a lecture given at the International Congress of Physics, Paris, 1900. What are the similarities and (...) differences between these two classifications? My main purpose is to provide a possible equivalence between the two classifications in order to clarify the role of hypotheses in Poincaré’s epistemology of natural science. The discussion will be based on the two fundamental texts mentioned above and on the contrast between Poincaré’s use of the notion of hypothesis and that of some of his contemporaries. (shrink)