The purpose of this paper is to show the argument-establishing features of a Renaissance altarpiece. Looking to Panofsky’s seminal studies and to more recent contributions, this essay shows how in a special environment like the Florentine pre-Renaissance, people could easily relate to the evocative and contrastive potential of images. In the Santa Lucia de’ Magnoli Altarpiece painted by Domenico Veneziano we see an interesting dialogue between the main piece and the predella panels. This juxtaposition can be formalized into a basic (...) argumentative text. (shrink)