It is argued in this paper that the valid argument forms coming under the general heading of Demonstrative Induction have played a highly significant role in the history of theoretical physics. This situation was thoroughly appreciated by several earlier philosophers of science and deserves to be more widely known and understood.

I offer an explicit account of the underdetermination thesis as well as of the many challenges it poses to scientific realism; a way to answer to these challenges is explored and outlined, by shifting attention to the content of theories. I argue that, even if we have solid grounds (as I contend we do) to support that some varieties of the underdetermination thesis are true, scientific realism can still offer an adequate picture of the aims and achievements of science.