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  1. International coverage of GLP-1 receptor agonists: a review and ethical analysis of discordant approaches.Johan Dellgren, Govind Persad & Ezekiel J. Emanuel - 2024 - The Lancet 404 (10455):902-906.
    This Viewpoint analyzes policies for covering GLP-1 receptor agonist drugs for obesity treatment across 13 high-income countries. It identifies four key lessons for developing coverage policies: 1) using up-to-date cost-effectiveness analyses that incorporate new evidence of benefits, 2) negotiating lower prices while preserving innovation incentives, 3) prioritizing coverage for specific populations rather than issuing blanket denials, and 4) treating obesity medications similarly to high-cost drugs for other conditions. It argues that blanket coverage denials are unethical and that countries should implement (...)
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  • Ethical Approaches to Limiting Overall Costs for Glucagon-Like Peptide-1 Receptor Agonists for Weight Management.Johan Dellgren, Ezekiel Emanuel & Govind Persad - forthcoming - Annals of Internal Medicine.
    This article evaluates seven strategies for managing the high costs of GLP-1 receptor agonists (GLP-1RAs) like semaglutide and tirzepatide for weight management: complete exclusion of coverage, annual cost increase caps, lifetime cost caps, tiered access, formulary reevaluation, subscription payment models, and patent reform. The authors assess each strategy against three ethical objectives: benefiting people and preventing harm, showing equal moral concern, and mitigating disadvantage. Complete coverage exclusions, arbitrary reimbursement caps, and lifetime limits are deemed unethical as they fail to meet (...)
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  • De Minimis Risk: A Proposal for a New Category of Research Risk.Rosamond Rhodes - 2011 - American Journal of Bioethics 11 (11):1-7.
    In this article the authors reflect on regulations which have been developed to protect research subjects and data in research which uses human subjects. They suggest that regulations related to informed consent and privacy protection are burdensome in research which uses human subjects. They argue that a new category of research risk must be established which informs research subjects of the level of risk that they will be exposed to by participating in the research.
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