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  1. Reviewing the Unsubstantiated Claims for the Methodological Superiority of 'Placebo' over 'Active' Controlled Trials: Reply to Open Peer Commentaries.Jeremy Howick - 2009 - American Journal of Bioethics 9 (9):5-7.
    A resilient issue in research ethics is whether and when a placebo-controlled trial is justified if it deprives research subjects of a recognized treatment. The clinicians' moral duty to provide the best available care seems to require the use of ‘active’ controlled trials that use an established treatment as a control whenever such a therapy is available. In another regard, ACTs are supposedly methodologically inferior to PCTs. Hence, the moral duty of the clinical researcher to use the best methods will (...)
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