Germ-line genetic interventions, like all medicine, can present opportunities to remove suffering, save and prolong human life, and support the conditions for successful human performance. Like all medicine, these interventions also present risks that reflect fallen humans’ age-old egocentric ambition to secure their health and improve their quality of life by relying exclusively on their own power, wisdom, and technical means. Moreover, man has always been tempted to overstep Divine prohibitions and to disregard his own calling to become deified by (...) grace. Wherever man succumbs to such tendencies, this inescapably leads to a disruption of the vital relationship between man and God. The legitimacy of the intervention itself depends on the theological status of the genome. Orthodox theology recognizes that the human genome, just as everything else that is created, must be understood in terms of its relationship to God. This consideration, however, does not mean that it can be idolized or is therefore untouchable. Interventions and alterations can be accepted within the constraints set by God, as formulated in the theology of creative logoi of beings in the teaching of the Fathers of the Church, and thus in view of man’s divine vocation. The Christian acceptability or inacceptability of human germ-line gene therapy depends directly on the extent to which it accords with an Orthodox spiritual life, or else hinders such a life. In this sense, this intervention can be examined in the same way as the application of all medical knowledge. When this is used to relieve pain and is motivated by selfless love for one’s neighbor, then it can be considered God’s gift to humankind. When, however, it becomes an absolute and attempts to usurp the presence of God in human life, then use becomes abuse and modern man faces yet another form of idolatry, even though more refined than earlier forms. (shrink)