The priorities of French policy regarding genetically modified (GM) food shifted in the late 1990s from aggressive promotion to strict regulation based on precaution and separation of GM food. This paradigmatic policy change coincided with a rapid shift in the dominant meanings of GM food in larger French public discourses. Using data from media coverage, organizational documents, and in-depth interviews, the study examines the relationship between policy developments and GM food’s symbolic transformation. I argue that the interpretive dimension interacted with (...) and co-evolved incrementally with formal policy developments, and that it cannot be understood as epiphenomenal to political processes, or as preceding and propelling a policy change. I identify three mechanisms of symbolic transformation: (1) multiplication of meanings; (2) association with other salient issues; and (3) coupling with national identity (boundary work). Conversely, this symbolic transformation influenced the terms of political debates and viable strategies, influencing policy developments. The study also demonstrates how certain longstanding elements of French political culture shaped, and were changed or reproduced through, these processes. (shrink)