In this paper, we reject commonly accepted views on fundamentality in science, either based on bottom-up construction or top-down reduction to isolate the alleged fundamental entities. We do not introduce any new scientific methodology, but rather describe the current scientific methodology and show how it entails an inherent search for foundations of science. This is achieved by phrasing metaphysical assumptions into falsifiable statements and define as fundamental those that survive empirical tests. The ones that are falsified are rejected, and the (...) corresponding philosophical concept is demolished as a prejudice. Furthermore, we show the application of this criterion in concrete examples of the search for fundamentality in quantum physics and biophysics. (shrink)

No scientific conclusion follows automatically from a statistically non-significant result, yet people routinely use non-significant results to guide conclusions about the status of theories (or the effectiveness of practices). To know whether a non-significant result counts against a theory, or if it just indicates data insensitivity, researchers must use one of: power, intervals (such as confidence or credibility intervals), or else an indicator of the relative evidence for one theory over another, such as a Bayes factor. I argue Bayes factors (...) allow theory to be linked to data in a way that overcomes the weaknesses of the other approaches. Specifically, Bayes factors use the data themselves to determine their sensitivity in distinguishing theories (unlike power), and they make use of those aspects of a theory’s predictions that are often easiest to specify (unlike power and intervals, which require specifying the minimal interesting value in order to address theory). Bayes factors provide a coherent approach to determining whether non-significant results support a null hypothesis over a theory, or whether the data are just insensitive. They allow accepting and rejecting the null hypothesis to be put on an equal footing. Concrete examples are provided to indicate the range of application of a simple online Bayes calculator, which reveal both the strengths and weaknesses of Bayes factors. (shrink)

The present work introduces the neuropsychological paradigm as a new approach to studying ancient literature. In the first part of the article, an epistemological framework for the proper use of neuropsychology in relation to ancient literature is presented. The article then discusses neuropsychological methods of studying different human experiences and dimensions already addressed by ancient literatures. The experiences of human encounters with gods among ancient cultures are first considered, through the contributions of Julian Jaynes and Eric R. Dodds. The concepts (...) of right and left in the Bible, and that of soul are then discussed. Ecstatic experience in Paul of Tarsus is also presented, with a particular focus on glossolalia. Neuroscientific differences between mindful and unitive meditative practices are then described referring to ancient Buddhist literature, and finally a brief description of dreams in ancient Greek literature is proposed. Neuropsychology variously enables a more profound understanding of themes characterizing human experiences that ancient literature has already explored; these investigations prove that the collaboration of neuroscience and humanistic studies can return fruitful and interesting results. (shrink)

The replicability of findings in experimental psychology can be improved by distinguishing sharply between hypothesis-generating research and hypothesis-testing research. This distinction can be achieved by preregistration, a method that has recently attracted widespread attention. Although preregistration is fair in the sense that it inoculates researchers against hindsight bias and confirmation bias, preregistration does not allow researchers to analyze the data flexibly without the analysis being demoted to exploratory. To alleviate this concern we discuss how researchers may conduct blinded analyses. As (...) with preregistration, blinded analyses break the feedback loop between the analysis plan and analysis outcome, thereby preventing cherry-picking and significance seeking. However, blinded analyses retain the flexibility to account for unexpected peculiarities in the data. We discuss different methods of blinding, offer recommendations for blinding of popular experimental designs, and introduce the design for an online blinding protocol. (shrink)

In the past few hundred years, science has exerted an enormous influence on the way the world appears to human observers. Despite phenomenal accomplishments of science, science nowadays faces numerous challenges that threaten its continued success. As scientific inventions become embedded within human societies, the challenges are further multiplied. In this critical review, some of the critical challenges for the field of modern chemistry are discussed, including: (a) interlinking theoretical knowledge and experimental approaches; (b) implementing the principles of sustainability at (...) the roots of the chemical design; (c) defining science from a philosophical perspective that acknowledges both pragmatic and realistic aspects thereof; (d) instigating interdisciplinary research; (e) learning to recognize and appreciate the aesthetic aspects of scientific knowledge and methodology, and promote truly inspiring education in chemistry. In the conclusion, I recapitulate that the evolution of human knowledge inherently depends upon our ability to adopt creative problem-solving attitudes, and that challenges will always be present within the scope of scientific interests. (shrink)

A search for the terms ‘acceptability judgment tasks’ & ‘language’ and ‘grammaticality judgment tasks’ & ‘language’ produces results which report findings that are based on the exact same elicitation technique. Although certain scholars have argued that acceptability and grammaticality are two separable notions that refer to different concepts, there are contexts in which the two terms are used interchangeably. The present work shows that these two notions and their scales do not coincide: there are sentences that are acceptable, even though (...) they are ungrammatical, and sentences that are unacceptable, despite being grammatical. First we adduce a number of examples for both cases, including grammatical illusions, violations of Identity Avoidance, and sentences that involve a level of processing complexity that overloads the cognitive parser and tricks it into (un)acceptability. We then discuss whether the acceptability of grammatically ill-formed sentences entails that we actually assign a meaning to them. Last, it is shown that there are n ways of unacceptability, and two ways of ungrammaticality, in the absolute and the relative sense. Since the use of the terms ‘acceptable’ and ‘grammatical’ is often found in experiments that constitute the core of the evidential base of linguistics, disentangling their various uses is likely to aid the field reach a better level of terminological clarity. (shrink)

This essay argues that the field of bioethics should concern itself especially with the process of making moral sense that unfolds among clinicians, patients and family members during common but high-stakes conversations occurring on the front lines of practice. The essay outlines the parameters of a bioethics grounded in the moral experience of patients, families and practitioners. It challenges ethicists, educators, and clinician leaders to commit themselves to advocating and developing creative approaches to learning that will cultivate the moral sensibilities (...) of frontline clinicians in this critically important domain of practice. (shrink)