Metaphor and metonymy, on the mental level temporally rather than syntactically or semantically defined, show a close association to healthy and neurotic defense, respectively. When the mind functions optimally, reverberating issues of past and present domains inform each other bidirectionally like source and target of a metaphor. Neurotic defense, metonymically conflating past and present, is mental access barring (negative metonymy). Metaphor and positive metonymy, fundamental to how the mind works, are autopoietic devices organizing creative change. Trauma (lost metaphoricity) results in (...) negative metonymy. During psychoanalysis metonymic defenses and transferences get remetaphorized. Nested mentational configurations emerge sequentially as markers of increased awareness (clinical vignette): negative metonymy (target enigmatic); positive metonymy (accessing target); metaphor (domains seen in terms of each other). (shrink)