After Second World War public and political decision makers wished to correct the apparent negative consequences of science and technology. This resulted in a call for ethical responsibility in science and technology and a new generation of environmental regimes aimed at controlling or managing the consequences of human interaction with the environment. The claim of this paper is that the Precautionary Principle can be understood as a combination of these trends. The Precautionary Principle is presented and discussed in detail. In (...) particular it is specified a) when the Principle is to be used, b) what measures follow from the decision to use it, and c) who is to be consulted in democratic decisions of the use of the Principle. (shrink)

This article explores the question of how scientific uncertainty can be managed in medical decision making using the Advisory Committee on Immunization Practices as a case study. It concludes that where a high degree of technical consensus exists about the evidence and data, decision makers act according to a clear decision rule. If a high degree of technical consensus does not exist and uncertainty abounds, the decision will be based on a variety of criteria, including readily available resources, decision-process constraints, (...) and the available knowledge base, among other things. Decision makers employ a variety of heuristic devices and techniques, thereby employing a pragmatic approach to uncertainty in medical decision making. The article concludes with recommendations for managing scientific uncertainty in medical decision making. (shrink)