As a way forward in assessing how the Old Testament wisdom tradition might speak to decisions in a modern medical context, in this paper, I propose exploring the iconographic function of the “tree of life” in the Old Testament, which is consistently associated with both wisdom as well as life and health, in order to tease out two-related issues that can help in providing a Christian theological framework for thinking about the problem of the medicalization of risk: first, how should (...) the natural and good human desire for health and long life be framed in terms of the pursuit of wisdom? And, second, how might a sapientially formed character approach risk and uncertainty in making medical decisions? The answers to these questions help establish a framework in which more specific questions related to the medicalization of risk can be assessed. As such, this paper is deliberately programmatic and perspectival rather than prescriptive. (shrink)