This study explored the associations between physical activity anxiety levels, and the perception of satisfaction of basic psychological needs, during Coronavirus Disease 2019 lockdown. Thus, 1,404 participants ranging from 18 to 89 years old completed a questionnaire in the period between 1st and 15th April 2021. The survey included sociodemographic data and the following validated instruments: the International Physical Activity Questionnaire, the Basic Need General Satisfaction Scale and the State-Trait Anxiety Inventory. The Kruskal-Wallis test was performed to examine variation in (...) anxiety levels and BPN satisfaction according to PA category. Spearman’s Rho correlations coefficients were used to determine the association between anxiety levels and psychological needs. Individuals presenting a higher level of PA revealed lower levels of anxiety-state. Differences between elements from different levels of PA were found for the autonomy, competence, and relatedness psychological needs, suggesting that those who feel their BPN as more satisfied have higher levels of PA. The study found statistically significant correlations between anxiety-state and the satisfaction of the needs for autonomy, competence, and relatedness. These findings support the importance that PA has in the anxiety levels during social isolation, emphasizing the importance of multidisciplinary teams in an individual-based approach. (shrink)