Neuroscience is a laboratory-based science that spans multiple levels of analysis from molecular genetics to behavior. At every level of analysis experiments are designed in order to answer empirical questions about phenomena of interest. Understanding the nature and structure of experimentation in neuroscience is fundamental for assessing the quality of the evidence produced by such experiments and the kinds of claims that are warranted by the data. This article provides a general conceptual framework for thinking about evidence and experimentation in (...) neuroscience with a particular focus on two research areas: cognitive neuroscience and cognitive neurobiology. (shrink)

This paper deals with the following question: What features of modern natural science are responsible for the fact that, of all forms of science, this form is technologically exploitable? The three notions: concept of nature, epistemic ideal, and experiment, suggest the most important components of my answer. I will argue, first, that only the peculiar interplay of the modern concept of nature with an epistemic ideal attuned to it can cast experiment in the specific, highly central role it plays in (...) the pursuit of knowledge about nature. It will then become clear that the form of science in which experiment plays such a role will, necessarily, prove technologically exploitable. (shrink)

Descriptive accounts of the nature of explanation in neuroscience and the global goals of such explanation have recently proliferated in the philosophy of neuroscience and with them new understandings of the experimental practices of neuroscientists have emerged. In this paper, I consider two models of such practices; one that takes them to be reductive; another that takes them to be integrative. I investigate those areas of the neuroscience of learning and memory from which the examples used to substantiate these models (...) are culled, and argue that the multiplicity of experimental protocols used in these research areas presents specific challenges for both models. In my view, these challenges have been overlooked largely because philosophers have hitherto failed to pay sufficient attention to fundamental features of experimental practice. I demonstrate that when we do pay attention to such features, evidence for reduction and integrative unity in neuroscience is simply not borne out. I end by suggesting some new directions for the philosophy of neuroscience that pertain to taking a closer look at the nature of neuroscientific experiments. (shrink)

Abstract: The aim of this paper is to analyse and criticize the argument of the experimenters' regress proposed by Harry Collins in 1985. In order to do that, I begin with an introduction to the experiments that aimed to detect gravity waves performed by Joseph Weber during 1970, then I analyse and discuss both forms of the argument: the epistemological and the ontological. Finally, after giving an outline of a theory of experimental reproduction and an explication of the concept of (...) replication, I propose two ways of avoiding the experimenters' regress. (shrink)