This article will explore the historical account and political actualisation of Machiavelli and La Boétie in the work of Claude Lefort. In the 1970s, Lefort renewed the interpretation of Machiavelli and La Boétie by underlining their common ‘radical humanism’. The long-overlooked insights into desire and social division of the two Renaissance thinkers underline the subversive potential of humanism against its common ideological and oligarchic uses. But the history of radical humanism cannot be separated from its topicality, as it is one (...) of the germs of the democratic revolution. This radicalism echoes and inspires Lefort's agonistic theory of democracy. After Machiavelli and La Boétie, his work grapples with the continued dependency of the subjects on visible and invisible masters. Indeed, according to Lefort, contemporary societies long for certainty and remain haunted by servitude in the form of ideology (be it bourgeois, totalitarian or invisible). (shrink)