This article explores hamartiological questions at the interface of evolutionary biology and theology. Such questions include the problem of evil, the possibility of a historical fall, and the meaning of human sinfulness in light of biology. First, I examine some of the leading accounts of animal theodicy, including John Schneider's aesthetic theodicy, Christopher Southgate's compound theodicy, and Joshua Moritz's free creatures’ defense. Second, I review several non‐lapsarian accounts of how sin originated within the human story (e.g., Robert Russell's concept of (...) entropy as the physical origin of sin). Then third, I discuss noteworthy attempts to revise the doctrine of original sin in light of evolutionary psychology. Although the quest for a post‐Darwinian doctrine of sin has prompted fascinating areas of research, I conclude that an evolutionary hamartiology remains a remarkably difficult project. (shrink)