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  1. What is a Virus? The Case of Tobacco Mosaic Disease.Ton van Helvoort - 1991 - Studies in History and Philosophy of Science Part A 22 (4):557-588.
    It is argued that the major interpretations of tobacco mosaic virus which were suggested in the first half of the 20th century can be ordered into two conflicting approaches. It is shown that explaining the existence of these different approaches as views from different perspectives, is a mistaken metaphor. The different approaches resulted in the "construction" of different research objects as answers to the questions "What is a virus"? Although these different conceptions did exclude each other, they co-existed because of (...)
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  • The Hydra Model - a Model for What?Alfred Gierer - 2012 - International Journal of Developmental Biology 56:437-445.
    The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means (...)
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  • Predictive Hypotheses Are Ineffectual in Resolving Complex Biochemical Systems.Michael Fry - 2018 - History and Philosophy of the Life Sciences 40 (2):25.
    Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical (...)
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  • Bacteriophage Biology and Kenneth Schaffner's Rendition of Developmentalism.Gregory J. Morgan - 2001 - Biology and Philosophy 16 (1):85-92.
    In this paper I consider Kenneth Schaffner''s(1998) rendition of ''''developmentalism'''' from the point of viewof bacteriophage biology. I argue that the fact that a viablephage can be produced from purified DNA and host cellularcomponents lends some support to the anti-developmentalist, ifthey first show that one can draw a principled distinctionbetween genetic and environmental effects. The existence ofhost-controlled phage host range restriction supports thedevelopmentalist''s insistence on the parity of DNA andenvironment. However, in the case of bacteriophage, thedevelopmentalist stands on less firm (...)
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  • Experiment, Difference, and Writing: II. The Laboratory Production of Transfer RNA.Hans-Jörg Rheinberger - 1991 - Studies in History and Philosophy of Science Part A 23 (3):389-422.
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