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  1. Holistic biology: Back on stage? Comments on post-genomics in historical perspective.Alfred Gierer - 2002 - Philosophia Naturalis 39 (1):25-44.
    A strong motivation for the human genome project was to relate biological features to the structure and function of small sets of genes, and ideally to individual genes. However, it is now increasingly realized that many problems require a "systems" approach emphasizing the interplay of large numbers of genes, and the involvement of complex networks of gene regulation. This implies a new emphasis on integrative, systems theoretical approaches. It may be called 'holistic' if the term is used without irrational overtones, (...)
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  • The Animal Economy as Object and Program in Montpellier Vitalism.Charles T. Wolfe & Motoichi Terada - 2008 - Science in Context 21 (4):537-579.
    Our aim in this paper is to bring to light the importance of the notion of économie animale in Montpellier vitalism, as a hybrid concept which brings together the structural and functional dimensions of the living body – dimensions which hitherto had primarily been studied according to a mechanistic model, or were discussed within the framework of Stahlian animism. The celebrated image of the bee-swarm expresses this structural-functional understanding of living bodies quite well: “One sees them press against each other, (...)
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  • Teleomechanism redux? The conceptual hybridity of living machines in early modern natural philosophy.Charles T. Wolfe - manuscript
    We have been accustomed at least since Kant and mainstream history of philosophy to distinguish between the ‘mechanical’ and the ‘teleological’; between a fully mechanistic, quantitative science of Nature exemplified by Newton and a teleological, qualitative approach to living beings ultimately expressed in the concept of ‘organism’ – a purposive entity, or at least an entity possessed of functions. The beauty of this distinction is that it seems to make intuitive sense and to map onto historical and conceptual constellations in (...)
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  • Do organisms have an ontological status?Charles T. Wolfe - 2010 - History and Philosophy of the Life Sciences 32 (2-3):195-232.
    The category of ‘organism’ has an ambiguous status: is it scientific or is it philosophical? Or, if one looks at it from within the relatively recent field or sub-field of philosophy of biology, is it a central, or at least legitimate category therein, or should it be dispensed with? In any case, it has long served as a kind of scientific “bolstering” for a philosophical train of argument which seeks to refute the “mechanistic” or “reductionist” trend, which has been perceived (...)
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  • The notion of nature in chemistry.Joachim Schummer - 2003 - Studies in History and Philosophy of Science Part A 34 (4):705-736.
    If nature is by definition the object of the natural sciences, then the dichotomy ‘natural’ versus ‘chemical’, held by both chemists and nonchemists, suggests an idiosyncrasy of chemistry. The first part of the paper presents a selective historical analysis of the main notions of nature in chemistry, as developed in early Christian views of chemical crafts, alchemy, iatrochemistry, mechanical philosophy, organic chemistry, and contemporary drug research. I argue that the dichotomy as well as quasi-moral judgments of chemistry have been based (...)
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