American polygenism was a provocative scientific movement whose controversial claim that humankind did not share a common ancestor caused a firestorm among naturalists and the lay public beginning in the 1830s. This article gives specific attention to the largely overlooked religious ideas marshaled by American polygenists in their effort to construct race as a unit of analysis. I focus specifically on the thought of the American polygenist and renowned surgeon Dr Josiah Clark Nott (1804–73) of Mobile, Alabama. Scholars have claimed (...) that in his effort to establish a properly modern scientific view of race Nott was one of the first American naturalists to publicly denounce the notion of common human descent (monogenesis) as proclaimed in the Bible. I argue that despite his rejection of monogenesis, Nott’s racial theory remained squarely within the tradition of Christian ideas about the natural world. American polygenism provides an example of how scientific and religious ideas worked together in the minds of American antebellum thinkers in the development of novel theories about race and human origins. (shrink)