The concept of mechanism in biology has three distinct meanings. It may refer to a philosophical thesis about the nature of life and biology (‘mechanicism’), to the internal workings of a machine-like structure (‘machine mechanism’), or to the causal explanation of a particular phenomenon (‘causal mechanism’). In this paper I trace the conceptual evolution of ‘mechanism’ in the history of biology, and I examine how the three meanings of this term have come to be featured in the philosophy of biology, (...) situating the new ‘mechanismic program’ in this context. I argue that the leading advocates of the mechanismic program (i.e., Craver, Darden, Bechtel, etc.) inadvertently conflate the different senses of ‘mechanism’. Specifically, they all inappropriately endow causal mechanisms with the ontic status of machine mechanisms, and this invariably results in problematic accounts of the role played by mechanism-talk in scientific practice. I suggest that for effective analyses of the concept of mechanism, causal mechanisms need to be distinguished from machine mechanisms, and the new mechanismic program in the philosophy of biology needs to be demarcated from the traditional concerns of mechanistic biology. (shrink)

In this paper I claim that the goal of mapping and sequencing the human genome is not wholly new, but rather is an extension of an older project to map genes, a central aim of genetics since its birth. Thus, the discussion about the value of the HGP should not be posed in global terms of acceptance or rejection, but in terms of how it should be developed. The first section of this paper presents a brief history of the project. (...) The second section distinguishes among four kinds of issues relevant to an evaluation of the HGP: those economic and organizational issues related to the feasibility of the project; the ethical questions arising in the development of the project and the application of the data gathered; the empirical issues relevant to the scientific value of the project; and conceptual issues like reductionism and determinism relevant to understand the nature and scope of the project. In a third section, I analyze in detail whether the HGP and, more generally, molecular biology is reductionistic. (shrink)

This is an essay about ethics and environmental responsibility. The thesis is that biologic species qua species--not only as collections of individuals or as elements of ecosystems--deserve moral regard. The argument establishes moral considerability on powers and freedoms of relative self-determination and autonomy. It is argued that species are living beings in their own right with their own projects and interests which deserve special regard. The essay draws from the arguments of Plato, Aristotle, Plotinus, Boethius, Avicenna, Maimonides, Leibniz, Spinoza, Kant, (...) and others, concerning the moral value of natural beings, but situates itself in the contemporary dialogue of environmental ethics. Lengthy consideration is given to species concepts defended by evolution theorists, biological systematists, and ecologists. ;The argument claims that natural beings, including species, have moral value because they have projects and interests which make a legitimate, but not universal, claim on the moral agent. Beings make moral claims when they are integral and integrating, individual, and concreative--conditions comparable to those with which we describe the moral status of a person. We may call such beings rational by analogy to the integration and singularity of intellect, and confer upon them analogous moral consideration. They are due regard in proportion to their projects in the same sense that moral subjects are due regard for having the projects of moral subjects. (shrink)