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  1. Lightning in a Bottle: Complexity, Chaos, and Computation in Climate Science.Jon Lawhead - 2014 - Dissertation, Columbia University
    Climatology is a paradigmatic complex systems science. Understanding the global climate involves tackling problems in physics, chemistry, economics, and many other disciplines. I argue that complex systems like the global climate are characterized by certain dynamical features that explain how those systems change over time. A complex system's dynamics are shaped by the interaction of many different components operating at many different temporal and spatial scales. Examining the multidisciplinary and holistic methods of climatology can help us better understand the nature (...)
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  • The Nuremberg Code subverts human health and safety by requiring animal modeling.Ray Greek, Annalea Pippus & Lawrence A. Hansen - 2012 - BMC Medical Ethics 13 (1):1-17.
    The requirement that animals be used in research and testing in order to protect humans was formalized in the Nuremberg Code and subsequent national and international laws, codes, and declarations. We review the history of these requirements and contrast what was known via science about animal models then with what is known now. We further analyze the predictive value of animal models when used as test subjects for human response to drugs and disease. We explore the use of animals for (...)
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  • Human Stakeholders and the Use of Animals in Drug Development.Lisa A. Kramer & Ray Greek - 2018 - Business and Society Review 123 (1):3-58.
    Pharmaceutical firms seek to fulfill their responsibilities to stakeholders by developing drugs that treat diseases. We evaluate the social and financial costs of developing new drugs relative to the realized benefits and find the industry falls short of its potential. This is primarily due to legislation-mandated reliance on animal test results in early stages of the drug development process, leading to a mere 10 percent success rate for new drugs entering human clinical trials. We cite hundreds of biomedical studies from (...)
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  • Expectations for methodology and translation of animal research: a survey of health care workers.Ari R. Joffe, Meredith Bara, Natalie Anton & Nathan Nobis - 2015 - BMC Medical Ethics 16 (1):29.
    Health care workers often perform, promote, and advocate use of public funds for animal research ; therefore, an awareness of the empirical costs and benefits of animal research is an important issue for HCW. We aim to determine what health-care-workers consider should be acceptable standards of AR methodology and translation rate to humans.
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  • Letter to the Editor.Ray Greek - 2014 - Theoretical Medicine and Bioethics 35 (5):389-394.
    Dear Editor,The April 2014 issue of Theoretical Medicine and Bioethics [1] presented eight essays regarding the use of nonhuman animals in biomedical research. While I appreciate the essays concerning contemporary research—which were well written and offered new thinking from the fields of ethics and ethology—I believe the journal, via the topics and the authors chosen, failed to communicate the most important fact regarding the current science pertinent to the use of nonhuman animals in research.The foundational reason for using chimpanzees and (...)
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