Abstract Since modernity, the concept of subject supposes both an anthropocentric and a dualistic view of life and reality. In this study, we carry out an analytic interpretation of the Descartes’ notion of subject, in order to build a different dimension of the concept of subject. We discuss the activity of computing, as the manner by which the living subject relates with and in-forms the world. We further examine computing in the aging yeast as an example of living subject and (...) we try to comprehend the maturity of the subjectivity in Descartes’ res cogitans and in our proposed res computans . Content Type Journal Article Category Original Paper Pages 1-12 DOI 10.1007/s10516-011-9177-5 Authors María Belén Campero, Center of Philosophical Investigations, CONICET, Buenos Aires, Argentina Cristián Favre, Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Suipacha 570, S2002LRL Rosario, Argentina Journal Axiomathes Online ISSN 1572-8390 Print ISSN 1122-1151. (shrink)