We study the isomorphism relation on Borel classes of locally compact Polish metric structures. We prove that isomorphism on such classes is always classifiable by countable structures (equivalently: Borel reducible to graph isomorphism), which implies, in particular, that isometry of locally compact Polish metric spaces is Borel reducible to graph isomorphism. We show that potentially $\boldsymbol {\Pi }^{0}_{\alpha + 1}$ isomorphism relations are Borel reducible to equality on hereditarily countable sets of rank $\alpha $, $\alpha \geq 2$. We also study (...) approximations of the Hjorth-isomorphism game, and formulate a condition ruling out classifiability by countable structures. (shrink)