In 1869, Johann Friedrich Miescher discovered a new substance in the nucleus of living cells. The substance, which he called nuclein, is now known as DNA, yet both Miescher’s name and his theoretical ideas about nuclein are all but forgotten. This paper traces the trajectory of Miescher’s reception in the historiography of genetics. To his critics, Miescher was a “contaminator,” whose preparations were impure. Modern historians portrayed him as a “confuser,” whose misunderstandings delayed the development of molecular biology. Each of (...) these portrayals reflects the disciplinary context in which Miescher’s work was evaluated. Using archival sources to unearth Miescher’s unpublished speculations—including an analogy between the hereditary material and language, and a speculation that a series of asymmetric carbon atoms could account for hereditary variation—this paper clarifies the ways in which the past was judged through the lens of contemporary concerns. It also shows how organization, structure, function, and information were already being considered when nuclein was first discovered nearly 150 years ago. (shrink)

The marriage of Sally Peris Hughes (1895–1984) and Franz Schrader (1891–1962) in November 1920 launched a highly successful scientific collaboration that lasted over four decades. The Schraders were avid naturalists, adroit experimentalists, and keen theoreticians, and both had long, productive, and fruitful careers in zoology. They offer an extraordinarily rich case study that provides an insightful view of the work carried out in several areas of the life sciences from the 1920s to the 1960s—fieldwork, cytology, cytogenetics, and entomology—as well as (...) critical aspects of the social world of contemporary science. By focusing on the fieldwork the couple carried out in Mexico and Central America in the late 1920s and early 1930s, this paper seeks to illuminate how this collaborative scientific marriage embodies a collective, complex, and integrated personal and social arrangement that served to enhance both knowledge production and disciplinary development in several areas of science. It also reveals ways in which marriage could serve as a means to help both parties navigate and negotiate restrictive sociocultural norms and institutional arrangements in science involving gender, power, and authority in the early twentieth century. (shrink)