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  1. Non-epistemic values in shaping the parameters for evaluating the effectiveness of candidate vaccines: the case of an Ebola vaccine trial.Joby Varghese - 2021 - History and Philosophy of the Life Sciences 43 (2):1-15.
    This paper examines the case of Ebola, ça Suffit trial which was conducted in Guinea during Ebola Virus Disease (EVD) outbreak in 2015. I demonstrate that various non-epistemic considerations may legitimately influence the criteria for evaluating the efficacy and effectiveness of a candidate vaccine. Such non-epistemic considerations, which are social, ethical, and pragmatic, can be better placed and addressed in scientific research by appealing to non-epistemic values. I consider two significant features any newly developed vaccine should possess; (1) the duration (...)
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  • Influence and prioritization of non-epistemic values in clinical trial designs: a study of Ebola ça Suffit trial.Joby Varghese - 2018 - Synthese 198 (Suppl 10):2393-2409.
    The recent Ebola virus disease outbreak in Western African countries has raised questions regarding the feasibility of adopting conventional trial designs such as randomized controlled trials for conducting experimental trials in the midst of a fatal epidemic. In the context of Ebola ça Suffit trial conducted in Guinea for testing the efficacy and effectiveness of rVSV–ZEBOV, a candidate vaccine, I argue that the trial design and the methodologies adopted for the trial have been rightly chosen for their ethical appropriateness and (...)
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  • Selecting the Right Tool For the Job.Arthur L. Caplan, Carolyn Plunkett & Bruce Levin - 2015 - American Journal of Bioethics 15 (4):4-10.
    There are competing ethical concerns when it comes to designing any clinical research study. Clinical trials of possible treatments for Ebola virus are no exception. If anything, the competing ethical concerns are exacerbated in trying to find answers to a deadly, rapidly spreading, infectious disease. The primary goal of current research is to identify experimental therapies that can cure Ebola or cure it with reasonable probability in infected individuals. Pursuit of that goal must be methodologically sound, practical and consistent with (...)
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  • Ebola-challenge and revival of theoretical epidemiology: Why Extrapolations from early phases of epidemics are problematic.Peter Schuster - 2015 - Complexity 20 (5):7-12.
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