The ArugmentThis essay answers a single question: what was Robert Hooke, the Royal Society's curator of experiments, doing in his well-known 1665 work,Micrographia?Hooke was articulating a “universal cure of the mind” capable of bringing about a “reformation in Philosophy,” a change in philosophy's interpretive practices and organization. The work explicated the interpretive and political foundations for a community of optical instrument users coextensive with the struggling Royal Society. Standard observational practices would overcome the problem of using nonstandard instruments, while inherent (...) inrepresentation– the interpretive practice championed in the text – were important theological and political meanings. Hooke's kind of experimental philosophy undermined the claims made by “atheists” and “enthusiasts” – the enemies of the restored church and state – while also producing useful knowledge. Equally important, Hooke modeled the community described inMicrographiaupon the classicalres publica, but his community made important concessions to Restoration political realities, especially the growing role of commercial or transactional relationships. (shrink)

During the 1840s and 1850s the British embryologist and histologist Martin Barry (1802-1855) propounded a bold and original thesis about the microscopic structure of animal and vegetable tissue. He maintained that minute double spirals were virtually ubiquitous in the makeup of a wide range of structures. This paper considers how a claim of this kind was consonant with a romantic image of scientific creativity with which Barry identified. It describes his partially successful strategies to convince contemporaries of the veracity of (...) his claims. Major figures in the field, such as Richard Owen and Jan Evangelista Purkyně, affirmed that Barry's spirals were real objects in nature. Others, notably William Sharpey, became convinced that the spirals were mere artefacts and that Barry was deeply flawed as a scientific investigator. The ultimate rejection of his hypothesis had much to do with the moral repugnance that Barry's attempts to gain credit for a major discovery evoked among influential medical scientists. This negative assessment of Barry as an investigator reveals the lineaments of an alternative ethic of scientific practice. (shrink)

What is the relation between things and theories, the material world and its scientific representations? This is a staple philosophical problem that rarely counts as historically legitimate or fruitful. In the following dialogue, the interlocutors do not argue for or against realism. Instead, they explore changing relations between theories and things, between contested objects of knowledge and less contested, more everyday things. Widely seen as the life sciences' first general theory, the cell theory underwent dramatic changes during the nineteenth century. (...) The dialogue establishes that each successive version of the cell theory was formulated -- each identity of the object cell was formed -- around a different material : cork, cartilage, eggs in cleavage, muscle. Such things thus serve as exemplary materials, in ways not described by standard concepts like induction, theory -testing, theory -laden observation, and construction. Still, how can theories and perspective possibly be honed on things if these are apprehended differently by different observers according to their interests, training, culture, or indeed theories? The second part of the dialogue addresses this problem, partly through the verbal and visual schemata that were used by nineteenth-century microscopists and that are comparable to schemata in the visual arts. The third part of the dialogue considers the exemplary materials as a historical sequence, itself needing explanation. Theoretical change devolved partly from wider histories and geographies of the prevalence, availability, or scientific and cultural status of materials such as plants, animals, and muscle. (shrink)

These three books illustrate some key themes in the history of science and the history of microscopy. First is a new enthusiasm among some historians and philosophers of science to embrace the history of microscopy as an area worthy of study, a recognized area of investigation for the historian and philosopher of science. In so doing these historians have redefined the subject area from the more traditional and much researched history of microscopes, with its emphasis on the technical, to a (...) consideration of the community of practitioners of microscopy and the theoretical contexts in which they carried out their studies. They have attempted to view the practice of microscopy and its practitioners within a conceptual, philosophical, and social context. They have by no means excluded technical considerations, but have argued that those alone can explain neither the rise, flourishing, and apparent decline of microscopy in the seventeenth and eighteenth centuries, nor its resurgence in the nineteenth century. Rather, they have argued that an analysis of microscopy must include social and conceptual considerations in addition to the technical. With these three books we have moved at last from the history of microscopes to the history of microscopy, within the context of the history and philosophy of science. The history of microscopy can now take its place within the larger inter-disciplines of HPS and STS. (shrink)

In 1853, the young Thomas Henry Huxley published a long review of German cell theory in which he roundly criticized the basic tenets of the Schleiden-Schwann model of the cell. Although historians of cytology have dismissed Huxley's criticism as based on an erroneous interpretation of cell physiology, the review is better understood as a contribution to embryology. "The Cell-theory" presents Huxley's "epigenetic" interpretation of histological organization emerging from changes in the protoplasm to replace the "preformationist" cell theory of Schleiden and (...) Schwann (as modified by Albert von Kölliker), which posited the nucleus as the seat of organic vitality. Huxley's views influenced a number of British biologists, who continued to oppose German cell theory well into the twentieth century. Yet Huxley was pivotal in introducing the new German program of "scientific zoology" to Britain in the early 1850s, championing its empiricist methodology as a means to enact broad disciplinary and institutional reforms in British natural history. (shrink)